The anterior cingulate cortex (ACC) lies in a unique position in the brain, with connections to both the “emotional” limbic system and the “cognitive” prefrontal cortex. Thus, the ACC likely has an important role in integration of neuronal circuitry for affect regulation and can be identified as a distinctive region in understanding psychopathology. Affect-regulation, the ability to control and manage uncomfortable emotions, is a primary goal for mental health clinicians in treating psychopathology. 7 Avoidance of painful emotions is often the motivating force in negative behaviors such as substance abuse, binge eating, and suicide. These actions are taken as part of maladaptive approaches to control, avoid, or regulate painful emotions. Clinicians often treat patients by helping them to develop more adaptive coping mechanisms in regulating their emotions. Understanding the processes by which ACC contributes to regulation of emotions may assist clinicians in their therapeutic work.