[HTML][HTML] Interferon Gamma and Contact-dependent Cytotoxicity Are Each Rate Limiting for Natural Killer Cell–Mediated Antibody-dependent Chronic Rejection
CM Lin, RJ Plenter, M Coulombe, RG Gill - American Journal of …, 2016 - Elsevier
Natural killer (NK) cells are key components of the innate immune system. In murine cardiac
transplant models, donor-specific antibodies (DSA), in concert with NK cells, are sufficient to
inflict chronic allograft vasculopathy independently of T and B cells. In this study, we aimed
to determine the effector mechanism (s) required by NK cells to trigger chronic allograft
vasculopathy during antibody-mediated rejection. Specifically, we tested the relative
contribution of the proinflammatory cytokine interferon gamma (IFN-γ) versus the contact …
transplant models, donor-specific antibodies (DSA), in concert with NK cells, are sufficient to
inflict chronic allograft vasculopathy independently of T and B cells. In this study, we aimed
to determine the effector mechanism (s) required by NK cells to trigger chronic allograft
vasculopathy during antibody-mediated rejection. Specifically, we tested the relative
contribution of the proinflammatory cytokine interferon gamma (IFN-γ) versus the contact …