Acute and chronic rejection impact distinct compartments of cardiac allografts.
Intramyocardial mononuclear cell infiltrates define acute rejection, whereas chronic rejection
affects large arteries. Hearts transplanted from male to female C57BL/6 mice undergo acute
rejection with interstitial infiltrates at 2 weeks that resolve by 6 weeks when large arteries
develop arteriopathy. These processes are dependent on T cells because no infiltrates
developed in T cell–deficient mice and transfer of CD4 T cells restored T cell as well as …