[HTML][HTML] O-GlcNAcylation of NF-κB promotes lung metastasis of cervical cancer cells via upregulation of CXCR4 expression
CXC chemokine receptor 4 (CXCR4) stimulates cancer metastasis. NF-κB regulates CXCR4
expression in cancer cells, and O-GlcNAc modification of NF-κB promotes its transcriptional
activity. Here, we determined whether CXCR4 expression is affected by O-GlcNAcylation of
NF-κB in lung metastasis of cervical cancer. We found elevated levels of O-linked-N-
actylglucosamine transferase (OGT) and O-GlcNAcylation in cervical cancer cells compared
to those in non-malignant epithelial cells and detected increased expression of NF-κB p65 …
expression in cancer cells, and O-GlcNAc modification of NF-κB promotes its transcriptional
activity. Here, we determined whether CXCR4 expression is affected by O-GlcNAcylation of
NF-κB in lung metastasis of cervical cancer. We found elevated levels of O-linked-N-
actylglucosamine transferase (OGT) and O-GlcNAcylation in cervical cancer cells compared
to those in non-malignant epithelial cells and detected increased expression of NF-κB p65 …