[HTML][HTML] Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle …

CR Hauck, DA Hsia, DD Schlaepfer - Journal of Biological Chemistry, 2000 - ASBMB
The focal adhesion (FAK) non-receptor protein-tyrosine kinase (PTK) links both extracellular
matrix/integrin and growth factor stimulation to intracellular signals promoting cell migration.
Here we show that both transient and stable overexpression of the FAK C-terminal domain
termed FRNK (FAK-relatednon-kinase) inhibits serum and platelet-derived growth factor
(PDGF)-BB-induced vascular smooth muscle cell (SMC) migration in wound healing and in
vitro Boyden Chamber chemotaxis assays, respectively. Expression of FRNK, but not a point …