Relative distribution of fibronectin and type I, III, IV, V collagens in normal and atherosclerotic intima of human arteries

BV Shekhonin, SP Domogatsky, GL Idelson… - Atherosclerosis, 1987 - Elsevier
Spatial distribution of fibronectin and type 1, III, IV and V collagen has been investigated in
normal arterial intima, fatty streaks, and atherosclerotic plaques by indirect
immunofluorescence on transverse sections. Two distinct types of extracellular matrix were
revealed in atherosclerotic lesions. The fibrous plaques consisted mostly of interstitial
collagen types I and III, contained moderate amounts of type V and none of type IV collagen
or fibronectin. In the extracellular matrix of the fatty streaks and in some areas of the fibrous …