Antigen presentation in transplantation

ML Alegre, FG Lakkis, AE Morelli - Trends in immunology, 2016 - cell.com
ML Alegre, FG Lakkis, AE Morelli
Trends in immunology, 2016cell.com
Transplantation of solid organs between genetically distinct individuals leads, in the
absence of immunosuppression, to T cell-dependent transplant rejection. Activation of graft-
reactive T cells relies on the presentation of transplant-derived antigens (intact donor MHC
molecules or processed peptides on host MHC molecules) by mature dendritic cells (DCs).
This review focuses on novel insights regarding the steps for maturation and differentiation
of DCs that are necessary for productive presentation of transplant antigens to host T cells …
Transplantation of solid organs between genetically distinct individuals leads, in the absence of immunosuppression, to T cell-dependent transplant rejection. Activation of graft-reactive T cells relies on the presentation of transplant-derived antigens (intact donor MHC molecules or processed peptides on host MHC molecules) by mature dendritic cells (DCs). This review focuses on novel insights regarding the steps for maturation and differentiation of DCs that are necessary for productive presentation of transplant antigens to host T cells. These steps include the licensing of DCs by the microbiota, their activation and maturation following recognition of allogeneic non-self, and their capture of donor cell exosomes to amplify the presentation of transplant antigens.
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