Antigen-specific γδ T cells represent an early innate defense known to play an important role
in anti-mycobacterial immunity. We have investigated the immune functions of Vγ9Vδ2 T
cells from Broncho-Alveolar lavages (BAC) samples of active TB patients. We observed that
BAC Vγ9Vδ2 T cells presented a strong down-modulation of CD3 expression compared with
Vγ9Vδ2 T cells from peripheral blood. Furthermore, Vγ9Vδ2 T cells mainly showed a central
memory phenotype, expressed high levels of NK inhibitory receptors and TEMRA cells …