Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation
Background The receptor for advanced glycation end products (RAGE) shares common
ligands and signaling pathways with TLR4, a key mediator of house dust mite
(Dermatophagoides pteronyssinus)(HDM) sensitization. We hypothesized that RAGE and its
ligand high-mobility group box-1 (HMGB1) cooperate with TLR4 to mediate HDM
sensitization. Objectives To determine the requirement for HMGB1 and RAGE, and their
relationship with TLR4, in airway sensitization. Methods TLR4−/−, RAGE−/−, and RAGE …
ligands and signaling pathways with TLR4, a key mediator of house dust mite
(Dermatophagoides pteronyssinus)(HDM) sensitization. We hypothesized that RAGE and its
ligand high-mobility group box-1 (HMGB1) cooperate with TLR4 to mediate HDM
sensitization. Objectives To determine the requirement for HMGB1 and RAGE, and their
relationship with TLR4, in airway sensitization. Methods TLR4−/−, RAGE−/−, and RAGE …