[HTML][HTML] Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation
X Qin, Z Hao, Q Tian, Z Zhang, C Zhou, W Xie - Journal of Biological …, 2014 - ASBMB
Aminoacyl-tRNA synthetases are an ancient enzyme family that specifically charges tRNA
molecules with cognate amino acids for protein synthesis. Glycyl-tRNA synthetase (GlyRS)
is one of the most intriguing aminoacyl-tRNA synthetases due to its divergent quaternary
structure and abnormal charging properties. In the past decade, mutations of human GlyRS
(hGlyRS) were also found to be associated with Charcot-Marie-Tooth disease. However, the
mechanisms of traditional and alternative functions of hGlyRS are poorly understood due to …
molecules with cognate amino acids for protein synthesis. Glycyl-tRNA synthetase (GlyRS)
is one of the most intriguing aminoacyl-tRNA synthetases due to its divergent quaternary
structure and abnormal charging properties. In the past decade, mutations of human GlyRS
(hGlyRS) were also found to be associated with Charcot-Marie-Tooth disease. However, the
mechanisms of traditional and alternative functions of hGlyRS are poorly understood due to …