[HTML][HTML] Role of the nervous system in cancer metastasis

N Kuol, L Stojanovska, V Apostolopoulos… - Journal of Experimental & …, 2018 - Springer
Journal of Experimental & Clinical Cancer Research, 2018Springer
Cancer remains as one of the leading cause of death worldwide. The development of cancer
involves an intricate process, wherein many identified and unidentified factors play a role.
Although most studies have focused on the genetic abnormalities which initiate and promote
cancer, there is overwhelming evidence that tumors interact within their environment by
direct cell-to-cell contact and with signaling molecules, suggesting that cancer cells can
influence their microenvironment and bidirectionally communicate with other systems …
Abstract
Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have focused on the genetic abnormalities which initiate and promote cancer, there is overwhelming evidence that tumors interact within their environment by direct cell-to-cell contact and with signaling molecules, suggesting that cancer cells can influence their microenvironment and bidirectionally communicate with other systems. However, only in recent years the role of the nervous system has been recognized as a major contributor to cancer development and metastasis. The nervous system governs functional activities of many organs, and, as tumors are not independent organs within an organism, this system is integrally involved in tumor growth and progression.
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