[HTML][HTML] The phosphorylation state of CD3γ influences T cell responsiveness and controls T cell receptor cycling

J Dietrich, T Bäckström, JPH Lauritsen… - Journal of Biological …, 1998 - ASBMB
The T cell receptor (TCR) is internalized following activation of protein kinase C (PKC) via a
leucine (Leu)-based motif in CD3γ. Some studies have indicated that the TCR is recycled
back to the cell surface following PKC-mediated internalization. The functional state of
recycled TCR and the mechanisms involved in the sorting events following PKC-induced
internalization are not known. In this study, we demonstrated that following PKC-induced
internalization, the TCR is recycled back to the cell surface in a functional state. TCR …