[HTML][HTML] WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at …
T cell antigen receptor (TCR) engagement has been shown to activate pathways leading to
actin cytoskeletal polymerization and reorganization, which are essential for lymphocyte
activation and function. Several actin regulatory proteins were implicated in regulating the
actin machinery, such as members of the Wiskott-Aldrich syndrome protein (WASp) family.
These include WASp and the WASp family verprolin-homologous protein-2 (WAVE2).
Although WASp and WAVE2 share several structural features, the precise regulatory …
actin cytoskeletal polymerization and reorganization, which are essential for lymphocyte
activation and function. Several actin regulatory proteins were implicated in regulating the
actin machinery, such as members of the Wiskott-Aldrich syndrome protein (WASp) family.
These include WASp and the WASp family verprolin-homologous protein-2 (WAVE2).
Although WASp and WAVE2 share several structural features, the precise regulatory …