[HTML][HTML] Reprogramming tumor blood vessels for enhancing immunotherapy
M Schmittnaegel, M De Palma - Trends in cancer, 2017 - cell.com
M Schmittnaegel, M De Palma
Trends in cancer, 2017•cell.comAngiogenic blood vessels contribute to generating an immunosuppressive tumor
microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming
of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T
cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other
cancer immunotherapies.
microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming
of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T
cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other
cancer immunotherapies.
Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other cancer immunotherapies.
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