Galectin-1 research in T cell immunity: past, present and future
F Cedeno-Laurent, CJ Dimitroff - Clinical immunology, 2012 - Elsevier
Galectin-1 (Gal-1) is one of 15 evolutionarily conserved ß-galactoside-binding proteins that
display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is
variably expressed on immune cells and endothelial cells, though is commonly found and
secreted at high levels in cancer cells. It induces apoptosis in effector T cells through
homodimeric binding of N-acetyllactosamines on membrane glycoproteins (Gal-1 ligands).
There is also compelling evidence in models of cancer and autoimmunity that recombinant …
display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is
variably expressed on immune cells and endothelial cells, though is commonly found and
secreted at high levels in cancer cells. It induces apoptosis in effector T cells through
homodimeric binding of N-acetyllactosamines on membrane glycoproteins (Gal-1 ligands).
There is also compelling evidence in models of cancer and autoimmunity that recombinant …