[HTML][HTML] miR-21 is a negative modulator of T-cell activation
C Carissimi, N Carucci, T Colombo, S Piconese… - Biochimie, 2014 - Elsevier
Abstract microRNAs (miRNAs) are a class of small non-coding RNAs acting as post-
transcriptional regulators of gene expression and play fundamental roles in regulating
immune response and autoimmunity. We show that memory T-lymphocytes express higher
levels of miR-21 compared to naïve T-lymphocytes and that miR-21 expression is induced
upon TCR engagement of naïve T-cells. We identify bona fide miR-21 targets by direct
immuno-purification and profiling of AGO2-associated mRNAs in Jurkat cells over …
transcriptional regulators of gene expression and play fundamental roles in regulating
immune response and autoimmunity. We show that memory T-lymphocytes express higher
levels of miR-21 compared to naïve T-lymphocytes and that miR-21 expression is induced
upon TCR engagement of naïve T-cells. We identify bona fide miR-21 targets by direct
immuno-purification and profiling of AGO2-associated mRNAs in Jurkat cells over …