[HTML][HTML] The RNA-stabilizing protein HuR regulates the expression of ζ chain of the human T cell receptor-associated CD3 complex

VR Moulton, VC Kyttaris, YT Juang… - Journal of biological …, 2008 - ASBMB
T cell dysfunction is crucial to the pathogenesis of systemic lupus erythematosus (SLE);
however, the molecular mechanisms involved in the deficient expression of the T cell
receptor-associated CD3ζ chain in SLE are not clear. SLE T cells express abnormally
increased levels of an alternatively spliced isoform of CD3ζ that lacks a 562-bp region in its
3′-untranslated region (UTR). We showed previously that two adenosine/uridine-rich
elements (ARE) in this splice-deleted region of CD3ζ transcript are critical for the mRNA …