[HTML][HTML] mTOR links environmental signals to T cell fate decisions
NM Chapman, H Chi - Frontiers in immunology, 2015 - frontiersin.org
NM Chapman, H Chi
Frontiers in immunology, 2015•frontiersin.orgT cell fate decisions play an integral role in maintaining the health of organisms under
homeostatic and inflammatory conditions. The localized microenvironment in which
developing and mature T cells reside provides signals that serve essential functions in
shaping these fate decisions. These signals are derived from the immune compartment,
including antigens, co-stimulation, and cytokines, and other factors, including growth factors
and nutrients. The mechanistic target of rapamycin (mTOR), a vital sensor of signals within …
homeostatic and inflammatory conditions. The localized microenvironment in which
developing and mature T cells reside provides signals that serve essential functions in
shaping these fate decisions. These signals are derived from the immune compartment,
including antigens, co-stimulation, and cytokines, and other factors, including growth factors
and nutrients. The mechanistic target of rapamycin (mTOR), a vital sensor of signals within …
T cell fate decisions play an integral role in maintaining the health of organisms under homeostatic and inflammatory conditions. The localized microenvironment in which developing and mature T cells reside provides signals that serve essential functions in shaping these fate decisions. These signals are derived from the immune compartment, including antigens, co-stimulation, and cytokines, and other factors, including growth factors and nutrients. The mechanistic target of rapamycin (mTOR), a vital sensor of signals within the immune microenvironment, is a central regulator of T cell biology. In this review, we discuss how various environmental cues tune mTOR activity in T cells, and summarize how mTOR integrates these signals to influence multiple aspects of T cell biology.
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