Pathogenesis of human systemic lupus erythematosus: a cellular perspective

VR Moulton, A Suarez-Fueyo, E Meidan, H Li… - Trends in molecular …, 2017 - cell.com
VR Moulton, A Suarez-Fueyo, E Meidan, H Li, M Mizui, GC Tsokos
Trends in molecular medicine, 2017cell.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune
dysregulation and breakdown of tolerance to self-antigens, resulting in autoantibody
production, inflammation, and destruction of end-organs. Emerging evidence on the role of
these factors has increased our knowledge of this complex disease, guiding therapeutic
strategies and identifying putative biomarkers. Recent findings include the characterization …
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs. A complex interaction of genetics, environment, and hormones leads to immune dysregulation and breakdown of tolerance to self-antigens, resulting in autoantibody production, inflammation, and destruction of end-organs. Emerging evidence on the role of these factors has increased our knowledge of this complex disease, guiding therapeutic strategies and identifying putative biomarkers. Recent findings include the characterization of genetic/epigenetic factors linked to SLE, as well as cellular effectors. Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities. The intricate web of involved factors and pathways dictates the adoption of tailored therapeutic approaches to conquer this disease.
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