Cannabidiol reverses the reduction in social interaction produced by low dose Δ9-tetrahydrocannabinol in rats

DT Malone, D Jongejan, DA Taylor - Pharmacology Biochemistry and …, 2009 - Elsevier
While Δ9-tetrahydrocannabinol (THC) is the main psychoactive constituent of the cannabis
plant, a non-psychoactive constituent is cannabidiol (CBD). CBD has been implicated as a
potential treatment of a number of disorders including schizophrenia and epilepsy and has
been included with THC in a 1: 1 combination for the treatment of conditions such as
neuropathic pain. This study investigated the effect of THC and CBD, alone or in
combination, on some objective behaviours of rats in the open field. Pairs of rats were …