Biliary copper excretion in acutely and chronically copper-loaded rats
M Harada, S Sakisaka, M Yoshitake, S Shakadoh… - Hepatology, 1993 - journals.lww.com
Biliary copper excretion was examined in rats with acute, continuous and chronic copper
loads. Copper was excreted into bile, and the concentration peaked 40 min after a venous
injection of copper sulfate (127 ng/gm body weight). The excretion was significantly inhibited
by colchicine. Therefore some copper may be transported in hepatocytes by a vesicular
pathway and excreted into bile. Biliary copper output increased over time and reached a
plateau 180 min after a continuous venous infusion of copper sulfate (318 ng/gm body …
loads. Copper was excreted into bile, and the concentration peaked 40 min after a venous
injection of copper sulfate (127 ng/gm body weight). The excretion was significantly inhibited
by colchicine. Therefore some copper may be transported in hepatocytes by a vesicular
pathway and excreted into bile. Biliary copper output increased over time and reached a
plateau 180 min after a continuous venous infusion of copper sulfate (318 ng/gm body …