[HTML][HTML] An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) …
W Wang, BC Roessler, KL Kirk - Journal of Biological Chemistry, 2014 - ASBMB
The CFTR channel is an essential mediator of electrolyte transport across epithelial tissues.
CFTR opening is promoted by ATP binding and dimerization of its two nucleotide binding
domains (NBDs). Phosphorylation of its R domain (eg by PKA) is also required for channel
activity. The CFTR structure is unsolved but homology models of the CFTR closed and open
states have been produced based on the crystal structures of evolutionarily related ABC
transporters. These models predict the formation of a tetrahelix bundle of intracellular loops …
CFTR opening is promoted by ATP binding and dimerization of its two nucleotide binding
domains (NBDs). Phosphorylation of its R domain (eg by PKA) is also required for channel
activity. The CFTR structure is unsolved but homology models of the CFTR closed and open
states have been produced based on the crystal structures of evolutionarily related ABC
transporters. These models predict the formation of a tetrahelix bundle of intracellular loops …