Specialised pro-resolving mediators of inflammation in inflammatory arthritis

AE Barden, M Moghaddami, E Mas, M Phillips… - … and Essential Fatty …, 2016 - Elsevier
Introduction Specialised pro-resolving mediators (SPM) are derived from n-3 long chain
polyunsaturated fatty acids (n-3FA). They promote resolution of inflammation and may
contribute to the beneficial effects of n-3FA in patients with arthritis. This study compared
SPM in knee effusions and plasma of patients with arthritis taking n-3FA, and plasma of
healthy volunteers taking n-3FA. Methods Thirty six patients taking n-3FA undergoing
arthrocentesis for an inflammatory knee effusion and 36 healthy volunteers who had taken n …