[HTML][HTML] Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes

KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li… - Journal of Biological …, 2004 - ASBMB
Alzheimer's disease-associated β-amyloid peptides (Aβ) are generated by the sequential
proteolytic processing of amyloid precursor protein (APP) by β-and γ-secretases. There is
growing evidence that cholesterol-and sphingolipid-rich membrane microdomains are
involved in regulating trafficking and processing of APP. BACE1, the major β-secretase in
neurons is a palmitoylated transmembrane protein that resides in lipid rafts. A subset of APP
is subject to amyloidogenic processing by BACE1 in lipid rafts, and this process depends on …