[HTML][HTML] JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
SC Cazanave, JL Mott, NA Elmi, SF Bronk… - Journal of Biological …, 2009 - ASBMB
Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-
dependent mechanism. However, the cellular processes by which JNK engages the core
apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain
incompletely understood. Thus, our aim was to determine whether JNK mediates induction
of BH3-only proteins during hepatocyte lipoapoptosis. The saturated FFA palmitate, but not
the monounsaturated FFA oleate, induces an increase in PUMA mRNA and protein levels …
dependent mechanism. However, the cellular processes by which JNK engages the core
apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain
incompletely understood. Thus, our aim was to determine whether JNK mediates induction
of BH3-only proteins during hepatocyte lipoapoptosis. The saturated FFA palmitate, but not
the monounsaturated FFA oleate, induces an increase in PUMA mRNA and protein levels …