Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair
C Brocas, JB Charbonnier, C Dhérin, S Gangloff… - DNA repair, 2010 - Elsevier
Eukaryotic DNA polymerase δ (Pol δ) activity is crucial for chromosome replication and DNA
repair and thus, plays an essential role in genome stability. In Saccharomyces cerevisiae,
Pol δ is a heterotrimeric complex composed of the catalytic subunit Pol3, the structural B
subunit Pol31, and Pol32, an additional auxiliary subunit. Pol3 interacts with Pol31 thanks to
its C-terminal domain (CTD) and this interaction is of functional importance both in DNA
replication and DNA repair. Interestingly, deletion of the last four C-terminal Pol3 residues …
repair and thus, plays an essential role in genome stability. In Saccharomyces cerevisiae,
Pol δ is a heterotrimeric complex composed of the catalytic subunit Pol3, the structural B
subunit Pol31, and Pol32, an additional auxiliary subunit. Pol3 interacts with Pol31 thanks to
its C-terminal domain (CTD) and this interaction is of functional importance both in DNA
replication and DNA repair. Interestingly, deletion of the last four C-terminal Pol3 residues …