[HTML][HTML] Proteomic analysis of ABCA1-null macrophages reveals a role for stomatin-like protein-2 in raft composition and toll-like receptor signaling

SM Chowdhury, X Zhu, JJ Aloor, KM Azzam… - Molecular & Cellular …, 2015 - ASBMB
Lipid raft membrane microdomains organize signaling by many prototypical receptors,
including the Toll-like receptors (TLRs) of the innate immune system. Raft-localization of
proteins is widely thought to be regulated by raft cholesterol levels, but this is largely on the
basis of studies that have manipulated cell cholesterol using crude and poorly specific
chemical tools, such as β-cyclodextrins. To date, there has been no proteome-scale
investigation of whether endogenous regulators of intracellular cholesterol trafficking, such …