Caveolae are flask-shaped invaginations at the plasma membrane that constitute a subclass
of detergent-resistant membrane domains enriched in cholesterol and sphingolipids and
that express caveolin, a caveolar coat protein. Autocrine motility factor receptor (AMF-R) is
stably localized to caveolae, and the cholesterol extracting reagent, methyl-β-cyclodextrin,
inhibits its internalization to the endoplasmic reticulum implicating caveolae in this distinct
receptor-mediated endocytic pathway. Curiously, the rate of methyl-β-cyclodextrin-sensitive …