Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

C Wrzesinski, CM Paulos, A Kaiser… - Journal of …, 2010 - journals.lww.com
Lymphodepletion before adoptive cell transfer (ACT)-based immunotherapies can enhance
anti-tumor responses by augmenting innate immunity, by increasing access to homeostatic
cytokines, and by depressing the numbers of regulatory T cells and myeloid-derived
suppressor cells. Although it is clear that high-dose total body irradiation given together with
hematopoietic stem cell (HSC) transplantation effectively enhances ACT, the relationship
between the intensity of lymphodepletion and tumor treatment efficacy has not been …