Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

K Wahlberg, M Arora, A Curtin, P Curtin, RO Wright… - Neurotoxicology, 2018 - Elsevier
Abstract Background Manganese (Mn) is an essential metal that can become neurotoxic at
elevated levels with negative consequences on neurodevelopment. We have evaluated the
influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10
and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue
concentrations early in life. Methods The study included 195 children with variable
environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal …