Manganism in the 21st century: the Hanninen lecture
BA Racette - Neurotoxicology, 2014 - Elsevier
Since the original description of the health effects of inhaled occupational manganese (Mn)
by Couper in 1837, an extensive literature details the clinical syndrome and
pathophysiology of what was thought to be a rare condition. In the last decade, conventional
wisdom regarding the clinicopathological effects of Mn has been challenged. Past
exposures to Mn were an order of magnitude higher than modern exposures in developed
countries; therefore, the clinical syndrome seen in the time of Couper is no longer typical of …
by Couper in 1837, an extensive literature details the clinical syndrome and
pathophysiology of what was thought to be a rare condition. In the last decade, conventional
wisdom regarding the clinicopathological effects of Mn has been challenged. Past
exposures to Mn were an order of magnitude higher than modern exposures in developed
countries; therefore, the clinical syndrome seen in the time of Couper is no longer typical of …