[HTML][HTML] Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion

KA Mitok, EC Freiberger, KL Schueler… - Journal of Biological …, 2018 - ASBMB
The mouse is a critical model in diabetes research, but most research in mice has been
limited to a small number of mouse strains and limited genetic variation. Using the eight
founder strains and both sexes of the Collaborative Cross (C57BL/6J (B6), A/J, 129S1/SvImJ
(129), NOD/ShiLtJ (NOD), NZO/HILtJ (NZO), PWK/PhJ (PWK), WSB/EiJ (WSB), and
CAST/EiJ (CAST)), we investigated the genetic dependence of diabetes-related metabolic
phenotypes and insulin secretion. We found that strain background is associated with an …