Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity

TP Chambers, L Santiesteban, D Gomez… - Toxicology, 2017 - Elsevier
Imatinib mesylate is an effective treatment for chronic myelogenous leukemia and
gastrointestinal stromal tumors. Although imatinib mesylate is highly tolerable, it has been
implicated in severe congestive heart failure in mouse models and patients. A hallmark of
imatinib mesylate-induced cardiotoxicity is mitochondrial dysfunction. The mitochondrial
scaffold Sab has been implicated in facilitating signaling responsible for mitochondrial
dysfunction in a c-Jun N-terminal Kinase (JNK)-dependent manner. We examined the …