[HTML][HTML] Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation

JW Chambers, PV LoGrasso - Journal of Biological Chemistry, 2011 - ASBMB
The JNK signaling cascade is critical for cellular responses to a variety of environmental and
cellular stimuli. Although gene expression aspects of JNK signal transduction are well
studied, there are minimal data on the physiological impact of JNK signaling. To bridge this
gap, we investigated how JNK impacted physiology in HeLa cells. We observed that
inhibition of JNK activity and JNK silencing with siRNA reduced the level of reactive oxygen
species (ROS) generated during anisomycin-induced stress in HeLa cells. Silencing p38 …