Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
S Win, TA Than, BHA Le, C García-Ruiz… - Journal of …, 2015 - Elsevier
Background & Aims Sustained c-Jun N-terminal kinase (JNK) activation by saturated fatty
acids plays a role in lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis
(NASH). We have reported that the interaction of JNK with mitochondrial Sab leads to
inhibition of respiration, increased reactive oxygen species (ROS), cell death and
hepatotoxicity. We tested whether this pathway underlies palmitic acid (PA)-induced
lipotoxicity in hepatocytes. Methods Primary mouse hepatocytes (PMH) from adeno-shlacZ …
acids plays a role in lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis
(NASH). We have reported that the interaction of JNK with mitochondrial Sab leads to
inhibition of respiration, increased reactive oxygen species (ROS), cell death and
hepatotoxicity. We tested whether this pathway underlies palmitic acid (PA)-induced
lipotoxicity in hepatocytes. Methods Primary mouse hepatocytes (PMH) from adeno-shlacZ …