Intermediate filament turnover is a highly dynamic process required to maintain tissue
integrity and is implicated in degenerative and regenerative processes. Despite these
essential roles, little is known about the mechanisms that cause the degradation of
intermediate filaments. Nevertheless, the last decade has seen the emergence of the
ubiquitin proteasome system, in particular E3 ubiquitin ligases, as important regulators.
Here, we will focus on the first identified factor controlling the degradation of the entire …