Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

N Chiang, CN Serhan - Molecular aspects of medicine, 2017 - Elsevier
The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious
unwanted side effects such as immune suppression. Uncontrolled inflammation is now
considered a pathophysiologic basis associated with many widely occurring diseases such
as cardiovascular disease, neurodegenerative diseases, diabetes, obesity and asthma, as
well as the classic inflammatory diseases, eg arthritis, periodontal diseases. The …