Regulated cell death in AKI

A Linkermann, G Chen, G Dong… - Journal of the …, 2014 - journals.lww.com
AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or
apoptosis. In the last two decades, tubular apoptosis has been shown in preclinical models
and some clinical samples from patients with AKI. Mechanistically, apoptotic cell death in
AKI may result from well described extrinsic and intrinsic pathways as well as ER stress.
Central converging nodes of these pathways are mitochondria, which become fragmented …