Whole mount immunofluorescence analysis of placentas from normotensive versus preeclamptic pregnancies
PE Zozzaro-Smith, ME Bushway, SA Gerber, D Hebert… - Placenta, 2015 - Elsevier
Introduction Defects in placental angiogenesis and spiral artery remodeling have been
proposed to play essential roles in the development of preeclampsia. However, the specific
molecular mechanism (s) responsible for aberrant placental angiogenesis in preeclampsia
are incompletely understood. The vascular endothelial growth factor receptors (VEGFR1,
R2, R3) and STAT3 have critical functions in normal blood vessel development, but their
potential roles in preeclampsia are currently unclear. In this study, we utilized a novel whole …
proposed to play essential roles in the development of preeclampsia. However, the specific
molecular mechanism (s) responsible for aberrant placental angiogenesis in preeclampsia
are incompletely understood. The vascular endothelial growth factor receptors (VEGFR1,
R2, R3) and STAT3 have critical functions in normal blood vessel development, but their
potential roles in preeclampsia are currently unclear. In this study, we utilized a novel whole …