Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma
RS Traister, CE Uvalle, GA Hawkins, DA Meyers… - Journal of Allergy and …, 2015 - Elsevier
Background Severe asthma remains poorly characterized, although it likely consists of at
least 1 phenotype with features of TH 2-like inflammation. IL1RL1, encoding both the IL-33
receptor, ST2L, and decoy receptor, sST2, has been genetically associated with asthma,
though the mechanism for susceptibility remains unknown. Objective Given previous data
supporting a role for IL1RL1 in TH 2 inflammation, we hypothesized that ST2L expression
might be increased in TH 2-like asthma and that expression levels would be associated with …
least 1 phenotype with features of TH 2-like inflammation. IL1RL1, encoding both the IL-33
receptor, ST2L, and decoy receptor, sST2, has been genetically associated with asthma,
though the mechanism for susceptibility remains unknown. Objective Given previous data
supporting a role for IL1RL1 in TH 2 inflammation, we hypothesized that ST2L expression
might be increased in TH 2-like asthma and that expression levels would be associated with …