[HTML][HTML] Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation
I Waern, A Lundequist, G Pejler, S Wernersson - Mucosal immunology, 2013 - Elsevier
Mast cells (MCs) are major effector cells contributing to allergic conditions. When activated,
they can release large amounts of active proteases, including chymase from their secretory
granules. Here we assessed the role of the chymase mouse mast cell protease 4 (mMCP-4)
in allergic airway inflammation induced by house-dust mite (HDM) extract. mMCP-4−/− mice
demonstrated elevated airway reactivity and eosinophilia compared with wild-type (WT)
animals, suggesting a protective role for mMCP-4 during the late inflammatory phase of the …
they can release large amounts of active proteases, including chymase from their secretory
granules. Here we assessed the role of the chymase mouse mast cell protease 4 (mMCP-4)
in allergic airway inflammation induced by house-dust mite (HDM) extract. mMCP-4−/− mice
demonstrated elevated airway reactivity and eosinophilia compared with wild-type (WT)
animals, suggesting a protective role for mMCP-4 during the late inflammatory phase of the …