Mechanisms of atrial fibrillation: lessons from animal models
S Nattel, A Shiroshita-Takeshita, BJJM Brundel… - Progress in …, 2005 - Elsevier
Studies in animal models have provided extremely important insights about atrial fibrillation
(AF). The classic mechanisms that still form the framework for our understanding of AF (focal
activity, single-circuit or “mother wave” reentry, and multiple circuit reentry) were established
based on animal studies almost 100 years ago. The past 10 years have witnessed a
tremendous acceleration of animal work in this area, including the development of a range
of AF models in clinically relevant pathological substrates (eg, atrial tachycardia remodeling …
(AF). The classic mechanisms that still form the framework for our understanding of AF (focal
activity, single-circuit or “mother wave” reentry, and multiple circuit reentry) were established
based on animal studies almost 100 years ago. The past 10 years have witnessed a
tremendous acceleration of animal work in this area, including the development of a range
of AF models in clinically relevant pathological substrates (eg, atrial tachycardia remodeling …