[HTML][HTML] A constitutive active MEK→ ERK pathway negatively regulates NF-κB-dependent gene expression by modulating TATA-binding protein phosphorylation
AB Carter, GW Hunninghake - Journal of Biological Chemistry, 2000 - ASBMB
Endotoxin-induced cytokine gene expression is regulated, in part, by NF-κB. We have
shown that both the ERK and p38 mitogen-activated protein (MAP) kinases are necessary
for cytokine gene transcription and that the p38 MAP kinase is required for NF-κB-driven
transcription, so we hypothesized that the MEK→ ERK pathway regulated NF-κB-driven
transcription as well. We found that a constitutive active MEK→ ERK pathway inhibited NF-
κB-driven transcription. In addition, both PD 98059 and a dominant negative ERK2 …
shown that both the ERK and p38 mitogen-activated protein (MAP) kinases are necessary
for cytokine gene transcription and that the p38 MAP kinase is required for NF-κB-driven
transcription, so we hypothesized that the MEK→ ERK pathway regulated NF-κB-driven
transcription as well. We found that a constitutive active MEK→ ERK pathway inhibited NF-
κB-driven transcription. In addition, both PD 98059 and a dominant negative ERK2 …