[HTML][HTML] RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells
J Ge, L Burnier, M Adamopoulou, MQ Kwa… - Journal of Biological …, 2018 - ASBMB
Mesenchymal stem cells (MSC) are suggested to be important progenitors of myofibroblasts
in fibrosis. To understand the role of Rho GTPase signaling in TGFβ-induced myofibroblast
differentiation of MSC, we generated a novel MSC line and its descendants lacking
functional Rho GTPases and Rho GTPase signaling components. Unexpectedly, our data
revealed that Rho GTPase signaling is required for TGFβ-induced expression of α-smooth
muscle actin (αSMA) but not of collagen I α1 (col1a1). Whereas loss of RhoA and Cdc42 …
in fibrosis. To understand the role of Rho GTPase signaling in TGFβ-induced myofibroblast
differentiation of MSC, we generated a novel MSC line and its descendants lacking
functional Rho GTPases and Rho GTPase signaling components. Unexpectedly, our data
revealed that Rho GTPase signaling is required for TGFβ-induced expression of α-smooth
muscle actin (αSMA) but not of collagen I α1 (col1a1). Whereas loss of RhoA and Cdc42 …