[HTML][HTML] Cell-mediated immunity to predict cytomegalovirus disease in high-risk solid organ transplant recipients
D Kumar, S Chernenko, G Moussa, I Cobas… - American journal of …, 2009 - Elsevier
Late-onset cytomegalovirus (CMV) disease commonly occurs after discontinuation of
antiviral prophylaxis. We determined the utility of testing CD8+ T-cell response against CMV
as a predictor of late-onset CMV disease after a standard course of antiviral prophylaxis.
Transplant patients at high-risk for CMV disease were enrolled. CD8+ T-cell-mediated
immunity (CMI) was tested using the QuantiFERON-CMV assay at baseline, 1, 2 and 3
months posttransplant by measurement of interferon-γ response to whole blood stimulation …
antiviral prophylaxis. We determined the utility of testing CD8+ T-cell response against CMV
as a predictor of late-onset CMV disease after a standard course of antiviral prophylaxis.
Transplant patients at high-risk for CMV disease were enrolled. CD8+ T-cell-mediated
immunity (CMI) was tested using the QuantiFERON-CMV assay at baseline, 1, 2 and 3
months posttransplant by measurement of interferon-γ response to whole blood stimulation …