Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases

B Mailaparambil, M Krueger, J Heinze… - Disease …, 2008 - content.iospress.com
B Mailaparambil, M Krueger, J Heinze, J Forster, A Heinzmann
Disease markers, 2008content.iospress.com
Toll like receptors (TLRs) are an essential part of the innate immune response. So far, ten
different TLRs were identified in humans. They recognize a wide range of microbial and viral
pathogens. Infection by respiratory syncytial virus (RSV) is still a major health problem,
about 2% of all children are hospitalised due to RSV bronchiolitis during their first 2 years of
live. TLR4 has already been described in association with RSV associated diseases by us
and others.
Abstract
Toll like receptors (TLRs) are an essential part of the innate immune response. So far, ten different TLRs were identified in humans. They recognize a wide range of microbial and viral pathogens. Infection by respiratory syncytial virus (RSV) is still a major health problem, about 2% of all children are hospitalised due to RSV bronchiolitis during their first 2 years of live. TLR4 has already been described in association with RSV associated diseases by us and others.
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