Cilostazol reduces atherosclerosis by inhibition of superoxide and tumor necrosis factor-α formation in low-density lipoprotein receptor-null mice fed high cholesterol
ABSTRACT This study shows that 6-[4-(1-cyclohexyl-1 H-tetrazol-5-yl) butoxy]-3, 4-dihydro-2
(1 H)-quinolinone (cilostazol) suppresses the atherosclerotic lesion formation in the low-
density lipoprotein receptor (Ldlr)-null mice. Ldlr-null mice fed a high cholesterol diet
showed multiple plaque lesions in the proximal ascending aorta including aortic sinus,
accompanied by increased macrophage accumulation with increased expression of
vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP …
(1 H)-quinolinone (cilostazol) suppresses the atherosclerotic lesion formation in the low-
density lipoprotein receptor (Ldlr)-null mice. Ldlr-null mice fed a high cholesterol diet
showed multiple plaque lesions in the proximal ascending aorta including aortic sinus,
accompanied by increased macrophage accumulation with increased expression of
vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP …
