Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients

E Beltrán, XH Nguyen, C Quériault, L Barateau… - Journal of …, 2019 - Elsevier
E Beltrán, XH Nguyen, C Quériault, L Barateau, Y Dauvilliers, K Dornmair, RS Liblau
Journal of Autoimmunity, 2019Elsevier
Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy
type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be
detected in the blood of NT1 patients. We compared the TCR repertoire of circulating
antigen-experienced CD4+ and CD8+ T cells from 13 recently diagnosed NT1 patients and
11 age-, sex-, and HLA-DQB1* 06: 02-matched healthy controls. We detected a bias in the
usage of TRAV3 and TRAV8 families, with public CDR3α motifs only present in CD4+ T cells …
Abstract
Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be detected in the blood of NT1 patients. We compared the TCR repertoire of circulating antigen-experienced CD4+ and CD8+ T cells from 13 recently diagnosed NT1 patients and 11 age-, sex-, and HLA-DQB1*06:02-matched healthy controls. We detected a bias in the usage of TRAV3 and TRAV8 families, with public CDR3α motifs only present in CD4+ T cells from patients with NT1. These findings may offer a unique tool to identify disease-relevant antigens.
Elsevier