Abnormal development of the thymus in" nude" mice

HH Wortis, S Nehlsen, JJ Owen - The Journal of Experimental Medicine, 1971 - rupress.org
HH Wortis, S Nehlsen, JJ Owen
The Journal of Experimental Medicine, 1971rupress.org
Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than
usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and
thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice
with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to
normal mice did not develop thymocytes. These experiments show that nude mice suffer
from a defect of the epithelial portion of the thymus rather than of the precursors of …
Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes.
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