PDGF receptors as targets in tumor treatment
A Östman, CH Heldin - Advances in cancer research, 2007 - Elsevier
Signaling through platelet‐derived growth factor (PDGF) receptors contributes to multiple
tumor‐associated processes. The recent introduction of clinically useful PDGF inhibitors
have the last years validated PDGF receptors in malignant and stromal cells as relevant
cancer drug targets. Mutational activation of PDGF receptor signaling in malignant cells has
been described in some rare tumor types such as dermatofibrosarcoma protuberans, a
subset of GISTs, and some hematologic malignancies. Furthermore, expression of PDGF …
tumor‐associated processes. The recent introduction of clinically useful PDGF inhibitors
have the last years validated PDGF receptors in malignant and stromal cells as relevant
cancer drug targets. Mutational activation of PDGF receptor signaling in malignant cells has
been described in some rare tumor types such as dermatofibrosarcoma protuberans, a
subset of GISTs, and some hematologic malignancies. Furthermore, expression of PDGF …